Inpharmaceutical water systems, the TOC value (Total Organic Carbon) is usually determined online. Since bacteria also consist to a large extent of hydrocarbons, the question arises as to whether information about the microbial status of the water system can also be obtained by means of TOC monitoring.
在制藥用水系統(tǒng)中，通常測定在線TOC值（總有機碳）。由于微生物也在很大程度上由碳氫化合物組成，因此出現(xiàn)了一個問題，即是否也可以通過TOC監(jiān)測獲得有關(guān)水系統(tǒng)微生物狀態(tài)的信息。
Unfortunately, this is not possible. There are fast microbiological test procedures (without agar plates), also for pharmaceutical water systems. However, these usually work with other technologies, often by particle measurement and fluorescence. However, it is not possible to convert TOC values into bacterial counts. Nor is it possible to draw any conclusions about a possible biofilm in the system.
不幸的是，這是不可能的?？焖傥⑸餃y試程序（不需要瓊脂平板），也適用于制藥用水系統(tǒng)。然而，這些通常與其他技術(shù)一起使用，通常是通過粒子測量和熒光。但是，不可能將TOC值轉(zhuǎn)換為細菌計數(shù)。也不可能對系統(tǒng)中可能的生物膜得出任何結(jié)論。
Bacteria in water systems are typically only present to a minimal extent in the free-flowing medium water (aquatic). They rather collect in a biofilm that grows on surfacesin places in the system with less flow (stationary). In order to trigger a measured value in the TOC system, the germs would have to flow through the TOC. It is always possible that a part of a biofilm tears off and moves through the system for a short time. But even then it is statistically rather unlikely that it will flow straight and reproducibly through the measuring system at the time of measurement. Short-term peaks in TOC monitoring could therefore be caused by a biofilm, but they do not have to be. And to get close to the limit value of 500 ppb TOC, the water would have to be contaminated so heavily that this would probably already be recognisable by turbidity and odour.
水系統(tǒng)中的微生物通常只有在自由流動的介質(zhì)水（水生）中才可以達到最低程度。它們聚集在生物膜中，生物膜生長在系統(tǒng)中流量較少（靜止）的地方的表面上。為了在TOC系統(tǒng)中觸發(fā)測量值，微生物必須流過TOC。生物膜的一部分總是有可能在短時間內(nèi)撕裂并在系統(tǒng)中移動。但即便如此，從統(tǒng)計學(xué)上講，它在測量時也不太可能直接且可重復(fù)地流過測量系統(tǒng)。因此，TOC監(jiān)測中的短期峰值可能是由生物膜引起的，但并非總是如此。為了接近 500 ppb TOC 的限度值，水必須受到非常嚴重的污染，以至于這可能已經(jīng)可以通過濁度和氣味來識別。
On the other hand, a very low TOC value in the water system is a very good starting point to prevent the formation of a biofilm, as the organic material is the food for the biofilm-forming bacteria.
另一方面，水系統(tǒng)中非常低的TOC值是防止生物膜形成的良好起點，因為有機物是形成生物膜的微生物的食物。
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